Tested in mice extended an anti -aging cocktail ”life by 30 percent – Cyprus Newspaper
Scientists in Europe tested in a mice with a “anti -aging cocktail” mice formed by bringing together two cancer drugs. The results are striking: The life expectancy of the mice increased by an average of 30 percent. Moreover, this extra time, not with disease or weakness, but a healthier old age.
The research was conducted at the Max Planck Aging Biology Institute in Germany. Rapamycin, one of the drugs used, was used to prevent rejection in organ transplantation, and previously shown to extend life in various animal experiments. Trametinib is known to extend life expectancy in another drug and fruit flies used in some types of cancer.
Researchers compared their effects by giving these drugs to mice both one by one and together:
Rapamycin only: 17–18 percent increase in life
Only Trametinib: 7–16 percent increase in life
Two Together: 26–35 percent increase in life
Old age is delayed, diseases slowed down
In the mice given with drug cocktails, only life did not grow; Tumor formation in the liver and spleen was delayed, inflammation of the brain, kidney and muscles decreased, and the deterioration of heart functions progressed more slowly. In addition, these mice remained more active in their old age and gained less weight.
Average life expectancy in female mice increased by 34.9 percent and 27.4 percent in men. The maximum life expectancy extended by 32.4 percent and 26.1 percent, respectively.
No side effect was not observed
Both drugs affect the signal path called Ras/Insulin/Tor, which affects the aging process in the body. However, since these drugs target different points, a stronger effect arises when used together. Moreover, no extra side effects were observed.
What does it mean to people?
Geneticist, one of the senior writers of the research. Linda Partridge stressed that these findings do not expect people to have the same effect on humans, but it is important in terms of extending the time of being healthy at a late age.
Since both drugs are already approved for use in people in the USA and Europe, clinical experiments can start in a short time. For example, Rapamycin, in another recent study, had extended the fertility of women during the perimenopausal period up to five years.
Research results were published in Nature Aging magazine.
