Osteoarthritis: Optimistic forecasts for new treatment treatments – BBC News in Serbian
More than 900 genetic connections with osteoarthritis, among them and 500 that have never been recorded, was discovered in the scientific study in English Šefilddo.
The British National Health Service Foundation (NHS) in teaching hospitals in Sheffield announced that this « a Target » global study on osteoarthritis is the largest of its kind.
Osteoarthritis, degenerative condition affecting joints, has about 595 million people around the world and is a leading cause of disability and chronic pain globally, according to the hospital fund.
In this study, genetic information was used almost two million people, and it was published in the journal Nature (Nature).
Led by Helmholc Center from Munich, the largest scientific research organization, almost half a million patients with osteoarthritis, among them, 1,000 volunteers from the boss, compared with DNA 1.5 million people who do not have this disease, British Foundation said.
The team identified 962 genetic variations that are more often in people with osteoarthritis.
More than 500 were not identified earlier, it is stated.
It is predicted that the number of osteoarthritis diseases will increase to a billion people by 2050. and despite the influence « there are currently no treatments that modify the course of the disease, » researchers said.
However, new scientific work « opens the way to potential new drugs and personalized therapies, » they added.
‘Conversion of existing therapy’
Professor Mark Vilkinson, honorary consultant in the Foundation and at the University of Sheffield, said that they are « extremely important » and will « open exciting new trails » for millions of people.
« In addition to identifying potential targets for drugs and opportunities to excise existing therapies in other states, this research has significantly improved our understanding of the basic biological mechanisms related, » this orthopedic surgeon said.
Eight biological processes found that regulate internal body systems and cell function, « throwing light on biological mechanisms », a foundation said.
Some of these genes have proteins that are approved for other states in drugs, which could accelerate treatment for treatment, added.
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