A great discovery of scientists about weight loss below one week

Scientists genetically modified the mice so that they could not produce cysteine ​​amino acids and followed a diet that was completely lacking in this formula. In just one week, the mice are amazing, 30%of their weight. This dramatic weight loss was due to the disruption of energy metabolism, caused by the coenzyme, which is a molecule that is critical in converting food into energy.

• Researchers genetically modified the mice so as not to produce the amino acid called cysteine.

• Mice lost 30%of their body weight in one week due to a cysteine-free diet.

• Cystein deficiency can cause difficulty in cell metabolism, increasing fat burning.

In a surprising new study, mice that were genetically modified to stop the cysteine ​​amino acid production and then kept them on a cysteine ​​-free diet in just one week lost 30 percent of their weight. NATURE Research published in the magazine on May 21 showed that the cysteine ​​deficiency is driving the body’s metabolism into chaos. Without this essential amino acid, the cells of mice could no longer effectively turn the food into energy. As a result of their bodies at a quick pace began to burn fat storesdesperately trying to meet their energy requirements.

A study led by researchers at the Faculty of Medicine in NY Grossman reveals how cells process fuel sources such as carbohydrates and fats. It also highlights the central role of a small molecule called (Coa). When the cysteine ​​levels decreased, the COA level began to fall, paralyzing the cell mechanism needed to convert the diet into energy.

COA is involved in more than 100 metabolic reactions and works with about 4%of the body’s enzymes. So far, it has been difficult to study directly because mice with faulty CoA production usually do not survive the juvenile. However, this research is the first to provide a detailed picture of how COA works in adult mice – and what happens when it fails.

A fundamental change in our views of metabolism

« Our surprising results show that low cysteine ​​levels have triggered a rapid fat burn at our experimental mice by activating the network of connected biological routes » Said the study co -author Dr. Evgeny Nudler, a professor at Julie Wilson Anderson at the Department of Biochemistry and Molecular Pharmacology at the Faculty of Medicine, and a researcher at Howard Hughes Medical Institute. « While promoting weight loss in the clinic is still a key future mission, we are currently the most excited about the profound, basic aspects of metabolism revealed in this study » Added Dr. Nudler.

The authors call for caution, as current results do not immediately suggest a new approach to weight loss, as cysteine ​​can be found in almost all foods. To achieve a truly cysteine ​​-free diet, patients would have to consume a specially compiled solution, which would be a challenge for most. Furthermore, since cysteine ​​is involved in a number of cellular routes, such as a drug that inhibits cysteine ​​production, it can make organs more vulnerable with everyday toxins, including medicines.

According to the authors of the study, it is worth considering that fruits, vegetables and legumes contain much lower cysteine ​​and precursor levels, sulfur-containing methionine amino acids such as red meats. While previous studies have been associated with low-sulfuric amino acid intake with health benefits, this study clarifies that these benefits are specifically due to cysteine ​​deficiency and not methionine restrictions. scitechdaily.

« Given that in mice, the achievement of maximum cysteine ​​withdrawal weight loss depends on both the diet and the gene deletion of the gene, we can now genetically restore cystein production in specific cells or tissues, and we can define each role in observed dramatic weight loss » Said co -author Dan L. Littman, PhD, Helen L. and Martin S. Kimmel’s molecular immunology professor at the Department of Pathology, and professor at the Department of Cell Biology at the Faculty of Medicine at Nye Grossman. « We hope that in the future we can divert some parts of this process to evoke similar weight loss in humans, but without complete removal of cysteine » Added Dr. Littman, who is also a researcher at Howard Hughes Medical Institute.

Furthermore, the team has found that cysteine ​​restriction activates both the integrated stress response (ISR), a signaling network that restores cell balance after stress, and oxidative stress response (OSR), which is a higher level of reactive oxygen (ROS) after glutathione, the primary antioxidant of the body. ROS can oxidize (remove electrons from cells) and damage sensitive cell parts such as DNA.